Gen 32:24 And Jacob was left alone; and there wrestled a man with him until the breaking of the day.
Eph 6:12 For we wrestle not against flesh and blood, but against principalities, against powers, against the rulers of the darkness of this world, against spiritual wickedness in high places.
There are two forms of wrestling mentioned in the Bible. One is with God and the other is with the devil and his forces. The form of wrestling undertaken in both is different from each other as chalk is to cheese. The wrestling with God is a fight one can never win; whereas, wrestling with the devil is certainly a fight one could win.